Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor

Lactisole, an inhibitor of the human sweet taste receptor, has a 2-phenoxypropionic acid skeleton and has been shown to interact with the transmembrane domain of the T1R3 subunit (T1R3-TMD) of the receptor. Another inhibitor, 2,4-DP, which shares the same molecular skeleton as lactisole, was confirm...

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Detalles Bibliográficos
Autores principales: Nakagita, Tomoya, Ishida, Akiko, Matsuya, Takumi, Kobayashi, Takuya, Narukawa, Masataka, Hirokawa, Takatsugu, Hashimoto, Makoto, Misaka, Takumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422327/
https://www.ncbi.nlm.nih.gov/pubmed/30883570
http://dx.doi.org/10.1371/journal.pone.0213552

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422327/
https://www.ncbi.nlm.nih.gov/pubmed/30883570
http://dx.doi.org/10.1371/journal.pone.0213552

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