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Ca(2+)/Calmodulin Binding to PSD-95 Downregulates Its Palmitoylation and AMPARs in Long-Term Depression

AMPA-type glutamate receptors (AMPARs) are clustered into functional nanodomains at postsynaptic sites through anchorage by the scaffolding protein, postsynaptic density protein-95 (PSD-95). The synaptic abundance of AMPARs is dynamically controlled in various forms of synaptic plasticity. Removal o...

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Detalles Bibliográficos
Autores principales: Chowdhury, Dhrubajyoti, Hell, Johannes W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422948/
https://www.ncbi.nlm.nih.gov/pubmed/30914943
http://dx.doi.org/10.3389/fnsyn.2019.00006