Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways

Known as co-stimulatory molecule, programmed death ligand-2 (PD-L2) contributes to T-cell exhaustion by interaction with programmed death-1 (PD-1) receptor, but its tumor cell-intrinsic signal effects have been little investigated. PD-L2 expression was detected by immunohistochemistry in 18 pairs of...

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Detalles Bibliográficos
Autores principales: Ren, Tingting, Zheng, Bingxin, Huang, Yi, Wang, Shidong, Bao, Xing, Liu, Kuisheng, Guo, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423010/
https://www.ncbi.nlm.nih.gov/pubmed/30886151
http://dx.doi.org/10.1038/s41419-019-1497-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423010/
https://www.ncbi.nlm.nih.gov/pubmed/30886151
http://dx.doi.org/10.1038/s41419-019-1497-1

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