Deferiprone: Pan-selective Histone Lysine Demethylase Inhibition Activity and Structure Activity Relationship Study

Deferiprone (DFP) is a hydroxypyridinone-derived iron chelator currently in clinical use for iron chelation therapy. DFP has also been known to elicit antiproliferative activities, yet the mechanism of this effect has remained elusive. We herein report that DFP chelates the Fe(2+) ion at the active...

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Detalles Bibliográficos
Autores principales: Khodaverdian, Verjine, Tapadar, Subhasish, MacDonald, Ian A., Xu, Yuan, Ho, Po-Yi, Bridges, Allison, Rajpurohit, Pragya, Sanghani, Bhakti A., Fan, Yuhong, Thangaraju, Muthusamy, Hathaway, Nathaniel A., Oyelere, Adegboyega K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423038/
https://www.ncbi.nlm.nih.gov/pubmed/30886160
http://dx.doi.org/10.1038/s41598-019-39214-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423038/
https://www.ncbi.nlm.nih.gov/pubmed/30886160
http://dx.doi.org/10.1038/s41598-019-39214-1

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