The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenylation in OA synovial samples was investigated, and the potenti...

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Detalles Bibliográficos
Autores principales: Ashraf, Sadaf, Radhi, Masar, Gowler, Peter, Burston, James J., Gandhi, Raj D., Thorn, Graeme J., Piccinini, Anna M., Walsh, David A., Chapman, Victoria, de Moor, Cornelia H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423048/
https://www.ncbi.nlm.nih.gov/pubmed/30886197
http://dx.doi.org/10.1038/s41598-019-41140-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423048/
https://www.ncbi.nlm.nih.gov/pubmed/30886197
http://dx.doi.org/10.1038/s41598-019-41140-1

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