Cargando…

The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis

Clinically, osteoarthritis (OA) pain is significantly associated with synovial inflammation. Identification of the mechanisms driving inflammation could reveal new targets to relieve this prevalent pain state. Herein, a role of polyadenylation in OA synovial samples was investigated, and the potenti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ashraf, Sadaf, Radhi, Masar, Gowler, Peter, Burston, James J., Gandhi, Raj D., Thorn, Graeme J., Piccinini, Anna M., Walsh, David A., Chapman, Victoria, de Moor, Cornelia H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423048/ https://www.ncbi.nlm.nih.gov/pubmed/30886197 http://dx.doi.org/10.1038/s41598-019-41140-1

Ejemplares similares

A Systematic Review of the Biological Effects of Cordycepin
por: Radhi, Masar, et al.
Publicado: (2021)

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin
por: Lee, Jong Bong, et al.
Publicado: (2019)

Refining surgical models of osteoarthritis in mice and rats alters pain phenotype but not joint pathology
por: Gowler, Peter R. W., et al.
Publicado: (2020)

Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis
por: Sagar, Devi Rani, et al.
Publicado: (2014)

Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis
por: Ashraf, Sadaf, et al.
Publicado: (2014)

Specificity factors in cytoplasmic polyadenylation
por: Charlesworth, Amanda, et al.
Publicado: (2013)

Lipidomic identification of plasma lipids associated with pain behaviour and pathology in a mouse model of osteoarthritis
por: Pousinis, P., et al.
Publicado: (2020)

Interplay between cellular changes in the knee joint, circulating lipids and pain behaviours in a slowly progressing murine model of osteoarthritis
por: Gowler, Peter R. W., et al.
Publicado: (2022)

Translational control by cytoplasmic polyadenylation in Xenopus oocytes
por: Radford, Helois E., et al.
Publicado: (2008)

Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects
por: Woolley, Victoria C., et al.
Publicado: (2020)

Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction
por: Wong, Ying Ying, et al.
Publicado: (2010)

Analgesic effects of the cathepsin K inhibitor L-006235 in the monosodium iodoacetate model of osteoarthritis pain
por: Nwosu, Lilian N., et al.
Publicado: (2018)

Differences in structural and pain phenotypes in the sodium monoiodoacetate and meniscal transection models of osteoarthritis
por: Mapp, P.I., et al.
Publicado: (2013)

Cordycepin delays postovulatory aging of oocytes through inhibition of maternal mRNAs degradation via DCP1A polyadenylation suppression
por: Li, Chong, et al.
Publicado: (2023)

Anxiety enhances pain in a model of osteoarthritis and is associated with altered endogenous opioid function and reduced opioid analgesia
por: Lillywhite, Amanda, et al.
Publicado: (2022)

Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment
por: Xia, Chen, et al.
Publicado: (2016)

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents
por: Wang, Ziwen, et al.
Publicado: (2019)

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi
por: Qin, Peng, et al.
Publicado: (2019)

Research Progress on Cordycepin Synthesis and Methods for Enhancement of Cordycepin Production in Cordyceps militaris
por: Wang, Li, et al.
Publicado: (2022)

Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthritis Pain
por: Huang, Junting, et al.
Publicado: (2017)

Mechanism of Activation of AMPK by Cordycepin
por: Hawley, Simon A., et al.
Publicado: (2020)

Neutral Lipid Content in Lipid Droplets: Potential Biomarker of Cordycepin Accumulation in Cordycepin-Producing Fungi
por: Qin, Peng, et al.
Publicado: (2019)

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain
por: Kelly, S, et al.
Publicado: (2015)

Cannabinoid CB(2) Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
por: Burston, James J., et al.
Publicado: (2013)

The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches
por: Deacon, Simon, et al.
Publicado: (2023)

The Anticancer Properties of Cordycepin and Their Underlying Mechanisms
por: Yoon, So Young, et al.
Publicado: (2018)

Cordycepin- melittin nanoconjugate intensifies wound healing efficacy in diabetic rats
por: Shaik, Rasheed A., et al.
Publicado: (2023)

Development of an efficient method for separation and purification of cordycepin from liquid fermentation of Cordyceps militaris and analysis of cordycepin antitumor activity
por: Liu, Peng-xiao, et al.
Publicado: (2023)

Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy
por: Tao, Xiao-Mei, et al.
Publicado: (2020)

Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin
por: Tuli, Hardeep S., et al.
Publicado: (2013)

Cordycepin prevents oxidative stress-induced inhibition of osteogenesis
por: Wang, Feng, et al.
Publicado: (2015)

Development of High Cordycepin-Producing Cordyceps militaris Strains
por: Kang, Naru, et al.
Publicado: (2017)

Functional Cordyceps Coffee Containing Cordycepin and β-Glucan
por: Song, Hyo-Nam
Publicado: (2020)

Cordycepin: A Biotherapeutic Molecule from Medicinal Mushroom
por: Soltani, Mohammad, et al.
Publicado: (2019)

Plant polyadenylation factors: conservation and variety in the polyadenylation complex in plants
por: Hunt, Arthur G, et al.
Publicado: (2012)

Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis
por: Haywood, Adrian R., et al.
Publicado: (2018)

Avascular necrosis of left Hip joint secondary to sickle cell anaemia for hip arthroplasty
por: Borkar, Sharmila, et al.
Publicado: (2015)

Robust anti‐nociceptive effects of monoacylglycerol lipase inhibition in a model of osteoarthritis pain
por: Burston, James J, et al.
Publicado: (2016)

Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33
por: Schönemann, Lars, et al.
Publicado: (2014)

Cordycepin Alleviates Anterior Cruciate Ligament Transection (ACLT)-Induced Knee Osteoarthritis Through Regulating TGF-β Activity and Autophagy [Retraction]
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qphqii42i9r60fa45ucvfk6uic