Amelioration of diabetic nephropathy by SGLT2 inhibitors independent of its glucose-lowering effect: A possible role of SGLT2 in mesangial cells

Several clinical studies have shown the beneficial effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on diabetic nephropathy. The underlying mechanisms are not fully understood. We found that administration of canagliflozin at a low dose (0.01 mg/kg/day) did not affect either blood glucos...

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Detalles Bibliográficos
Autores principales: Maki, Toshinobu, Maeno, Sayaka, Maeda, Yasutaka, Yamato, Mayumi, Sonoda, Noriyuki, Ogawa, Yoshihiro, Wakisaka, Masanori, Inoguchi, Toyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423112/
https://www.ncbi.nlm.nih.gov/pubmed/30886225
http://dx.doi.org/10.1038/s41598-019-41253-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423112/
https://www.ncbi.nlm.nih.gov/pubmed/30886225
http://dx.doi.org/10.1038/s41598-019-41253-7

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