The DNA damage induced by the Cytosine Deaminase APOBEC3A Leads to the production of ROS

Human apolipoprotein B mRNA-editing catalytic polypeptide-like 3 proteins (APOBEC3s or A3s) are cytosine deaminases that protect cells by introducing promutagenic uraciles in invading retro-elements. However as a drawback of this protective activity, A3s can also target cellular DNA, leading to DNA...

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Detalles Bibliográficos
Autores principales: Niocel, Mathilde, Appourchaux, Romain, Nguyen, Xuan-Nhi, Delpeuch, Mathilde, Cimarelli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423136/
https://www.ncbi.nlm.nih.gov/pubmed/30886206
http://dx.doi.org/10.1038/s41598-019-40941-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423136/
https://www.ncbi.nlm.nih.gov/pubmed/30886206
http://dx.doi.org/10.1038/s41598-019-40941-8

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