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DNAJB3 attenuates metabolic stress and promotes glucose uptake by eliciting Glut4 translocation

Failure of the heat shock response is a key event that leads to insulin resistance and type 2 diabetes. We recently showed that DNAJB3 co-chaperone is downregulated in obese and diabetic patients and that physical exercise restores its normal expression with a significant improvement of the clinical...

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Detalles Bibliográficos
Autores principales: Arredouani, Abdelilah, Diane, Abdoulaye, Khattab, Namat, Bensmail, Ilham, Aoude, Imad, Chikri, Mohamed, Mohammad, Ramzi, Abou-Samra, Abdul Badi, Dehbi, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423224/
https://www.ncbi.nlm.nih.gov/pubmed/30886231
http://dx.doi.org/10.1038/s41598-019-41244-8