Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm

BACKGROUND: Normal sperm function depends on appropriate intracellular calcium (Ca(i)(2+)) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by progesterone and intracellular alkalizati...

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Detalles Bibliográficos
Autores principales: Ghanbari, Hamideh, Keshtgar, Sara, Zare, Hamid Reza, Gharesi-Fard, Behrouz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Journal of Medical Sciences 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423429/
https://www.ncbi.nlm.nih.gov/pubmed/30936599

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423429/
https://www.ncbi.nlm.nih.gov/pubmed/30936599

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