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Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm
BACKGROUND: Normal sperm function depends on appropriate intracellular calcium (Ca(i)(2+)) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by progesterone and intracellular alkalizati...
Autores principales: | Ghanbari, Hamideh, Keshtgar, Sara, Zare, Hamid Reza, Gharesi-Fard, Behrouz |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Journal of Medical Sciences
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423429/ https://www.ncbi.nlm.nih.gov/pubmed/30936599 |
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