Cargando…

Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit

Human DNA polymerase delta (Polδ), a holoenzyme consisting of p125, p50, p68, and p12 subunits, plays an essential role in DNA replication, repair, and recombination. Herein, using multiple physicochemical and cellular approaches, we found that the p12 protein forms a dimer in solution. In vitro rec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khandagale, Prashant, Peroumal, Doureradjou, Manohar, Kodavati, Acharya, Narottam
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424025/ https://www.ncbi.nlm.nih.gov/pubmed/30885984 http://dx.doi.org/10.26508/lsa.201900323

Ejemplares similares

The ubiquitin-binding domain of DNA polymerase η directly binds to DNA clamp PCNA and regulates translesion DNA synthesis
por: Manohar, Kodavati, et al.
Publicado: (2021)

Identification of PCNA-interacting protein motifs in human DNA polymerase δ
por: Khandagale, Prashant, et al.
Publicado: (2020)

Comparative molecular dynamics studies of heterozygous open reading frames of DNA polymerase eta (η) in pathogenic yeast Candida albicans
por: Satpati, Suresh, et al.
Publicado: (2017)

Commensal Fungus Candida albicans Maintains a Long-Term Mutualistic Relationship with the Host To Modulate Gut Microbiota and Metabolism
por: Peroumal, Doureradjou, et al.
Publicado: (2022)

Characterization of proliferating cell nuclear antigen (PCNA) from pathogenic yeast Candida albicans and its functional analyses in S. Cerevisiae
por: Manohar, Kodavati, et al.
Publicado: (2015)

DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2021)

Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans
por: Patel, Shraddheya Kumar, et al.
Publicado: (2023)

The Pseudorabies Virus DNA Polymerase Accessory Subunit UL42 Directs Nuclear Transport of the Holoenzyme
por: Wang, Yi-Ping, et al.
Publicado: (2016)

Correction to ‘DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion’
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2021)

4-nitroquinoline 1-oxide induces immune cells death to onset early immunosuppression during oral squamous cell carcinoma development
por: Sahu, Satya Ranjan, et al.
Publicado: (2023)

The unstructured C-terminus of the τ subunit of Escherichia coli DNA polymerase III holoenzyme is the site of interaction with the α subunit
por: Jergic, Slobodan, et al.
Publicado: (2007)

The DNA polymerase III holoenzyme contains γ and is not a trimeric polymerase
por: Dohrmann, Paul R., et al.
Publicado: (2016)

Identification and characterization of a heterotrimeric archaeal DNA polymerase holoenzyme
por: Yan, Jiangyu, et al.
Publicado: (2017)

Interdomain connecting loop and J loop structures determine cross-species compatibility of PCNA
por: Kumari, Premlata, et al.
Publicado: (2021)

Organization of an Activator-Bound RNA Polymerase Holoenzyme
por: Bose, Daniel, et al.
Publicado: (2008)

Stepwise assembly of the human replicative polymerase holoenzyme
por: Hedglin, Mark, et al.
Publicado: (2013)

P50, the Small Subunit of DNA Polymerase Delta, Is Required for Mediation of the Interaction of Polymerase Delta Subassemblies with PCNA
por: Wang, Yujue, et al.
Publicado: (2011)

Crystal Structure of the Vaccinia Virus DNA Polymerase Holoenzyme Subunit D4 in Complex with the A20 N-Terminal Domain
por: Contesto-Richefeu, Céline, et al.
Publicado: (2014)

Dynamic Assembly and Disassembly of the Human DNA Polymerase δ Holoenzyme on the Genome In Vivo
por: Drosopoulos, William C., et al.
Publicado: (2020)

Long-Range PCR Amplification of DNA by DNA Polymerase III Holoenzyme from Thermus thermophilus
por: Ribble, Wendy, et al.
Publicado: (2015)

Structural basis for the assembly of the DNA polymerase holoenzyme from a monkeypox virus variant
por: Li, Yaning, et al.
Publicado: (2023)

Collision with duplex DNA renders Escherichia coli DNA polymerase III holoenzyme susceptible to DNA polymerase IV-mediated polymerase switching on the sliding clamp
por: Le, Thanh Thi, et al.
Publicado: (2017)

A distinct holoenzyme organization for two-subunit pyruvate carboxylase
por: Choi, Philip H., et al.
Publicado: (2016)

Tracking of progressing human DNA polymerase δ holoenzymes reveals distributions of DNA lesion bypass activities
por: Dannenberg, Rachel L, et al.
Publicado: (2022)

Interplay of macromolecular interactions during assembly of human DNA polymerase δ holoenzymes and initiation of DNA synthesis
por: Norris, Jessica L., et al.
Publicado: (2023)

A new role for proteins subunits of RNase P: stabilization of the telomerase holoenzyme
por: Garcia, P. Daniela, et al.
Publicado: (2020)

Production of Pentameric Cholera Toxin B Subunit in Escherichia coli
por: Dakterzada, Farida, et al.
Publicado: (2012)

Structure of a bacterial RNA polymerase holoenzyme open promoter complex
por: Bae, Brian, et al.
Publicado: (2015)

Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome
por: Yuan, Zuanning, et al.
Publicado: (2020)

The β Subunit of the Na(+)/K(+)-ATPase Follows the Conformational State of the Holoenzyme
por: Dempski, Robert E., et al.
Publicado: (2005)

Domain Structures and Inter-Domain Interactions Defining the Holoenzyme Architecture of Archaeal D-Family DNA Polymerase
por: Matsui, Ikuo, et al.
Publicado: (2013)

Live-Cell Analysis of Human Cytomegalovirus DNA Polymerase Holoenzyme Assembly by Resonance Energy Transfer Methods
por: Di Antonio, Veronica, et al.
Publicado: (2021)

Proteolysis of the Human DNA Polymerase Delta Smallest Subunit p12 by μ-Calpain in Calcium-Triggered Apoptotic HeLa Cells
por: Fan, Xiaoting, et al.
Publicado: (2014)

The DNA polymerase activity of Pol ε holoenzyme is required for rapid and efficient chromosomal DNA replication in Xenopus egg extracts
por: Shikata, Koh, et al.
Publicado: (2006)

Tracing the path of DNA substrates in active Tetrahymena telomerase holoenzyme complexes: mapping of DNA contact sites in the RNA subunit
por: Goldin, Svetlana, et al.
Publicado: (2012)

Yeast 9-1-1 complex acts as a sliding clamp for DNA synthesis by DNA polymerase ε
por: Acharya, Narottam, et al.
Publicado: (2022)

Lysine acetylation of the housekeeping sigma factor enhances the activity of the RNA polymerase holoenzyme
por: Kim, Ji-Eun, et al.
Publicado: (2020)

CaMKII autophosphorylation can occur between holoenzymes without subunit exchange
por: Lučić, Iva, et al.
Publicado: (2023)

Inherent low Erk and p38 activity reduce Fas Ligand expression and degranulation in T helper 17 cells leading to activation induced cell death resistance
por: Peroumal, Doureradjou, et al.
Publicado: (2016)

E. coli primase and DNA polymerase III holoenzyme are able to bind concurrently to a primed template during DNA replication
por: Bogutzki, Andrea, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_82m7el3aj3mlngk9a1qf8lpgrb