The Chromatin Structure of CRISPR-Cas9 Target DNA Controls the Balance between Mutagenic and Homology-Directed Gene-Editing Events

Gene editing based on homology-directed repair (HDR) depends on donor DNA templates and programmable nucleases, e.g., RNA-guided CRISPR-Cas9 nucleases. However, next to inducing HDR involving the mending of chromosomal double-stranded breaks (DSBs) with donor DNA substrates, programmable nucleases a...

Descripción completa

Detalles Bibliográficos
Autores principales: Janssen, Josephine M., Chen, Xiaoyu, Liu, Jin, Gonçalves, Manuel A.F.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424062/
https://www.ncbi.nlm.nih.gov/pubmed/30884291
http://dx.doi.org/10.1016/j.omtn.2019.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424062/
https://www.ncbi.nlm.nih.gov/pubmed/30884291
http://dx.doi.org/10.1016/j.omtn.2019.02.009

Ejemplares similares