A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity

The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the cell and how this regulation alters ferroptosis sensitivity is poorly understood. Using genome-wide human haploid genetic screening technology coup...

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Detalles Bibliográficos
Autores principales: Cao, Jennifer Yinuo, Poddar, Aunoy, Magtanong, Leslie, Lumb, Jennifer H., Mileur, Trevor R., Reid, Michael A., Dovey, Cole M., Wang, Jin, Locasale, Jason W., Stone, Everett, Cole, Susan P.C., Carette, Jan E., Dixon, Scott J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424331/
https://www.ncbi.nlm.nih.gov/pubmed/30726737
http://dx.doi.org/10.1016/j.celrep.2019.01.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424331/
https://www.ncbi.nlm.nih.gov/pubmed/30726737
http://dx.doi.org/10.1016/j.celrep.2019.01.043

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