Defects in assembly explain reduced antiviral activity of the G249D polymorphism in human TRIM5α

TRIM5α is an interferon inducible restriction factor which contributes to intrinsic defense against HIV infection by targeting the HIV capsid protein CA. Although human TRIM5α (huTRIM5α) does not potently inhibit HIV-1 infection, the ability of huTRIM5α to exhibit some control of HIV-1 infection is...

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Detalles Bibliográficos
Autores principales: Kömürlü, Sevnur, Bradley, Margret, Smolin, Nikolai, Imam, Sabrina, Pauszek, Raymond F., Robia, Seth L., Millar, David, Nakayama, Emi E., Shioda, Tatsuo, Campbell, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424450/
https://www.ncbi.nlm.nih.gov/pubmed/30889178
http://dx.doi.org/10.1371/journal.pone.0212888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424450/
https://www.ncbi.nlm.nih.gov/pubmed/30889178
http://dx.doi.org/10.1371/journal.pone.0212888

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