Aicardi–Goutières Syndrome associated mutations of RNase H2B impair its interaction with ZMYM3 and the CoREST histone-modifying complex

DNA-RNA hybrids arise in all cell types, and are removed by multiple enzymes, including the trimeric ribonuclease, RNase H2. Mutations in human RNase H2 result in Aicardi–Goutières syndrome (AGS), an inflammatory brain disorder notable for being a Mendelian mimic of congenital viral infection. Previ...

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Detalles Bibliográficos
Autores principales: Shapson-Coe, Alexander, Valeiras, Brenda, Wall, Christopher, Rada, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424451/
https://www.ncbi.nlm.nih.gov/pubmed/30889214
http://dx.doi.org/10.1371/journal.pone.0213553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424451/
https://www.ncbi.nlm.nih.gov/pubmed/30889214
http://dx.doi.org/10.1371/journal.pone.0213553

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