Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations

Individual instances of cancer are primarily a result of a combination of a small number of genetic mutations (hits). Knowing the number of such mutations is a prerequisite for identifying specific combinations of carcinogenic mutations and understanding the etiology of cancer. We present a mathemat...

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Detalles Bibliográficos
Autores principales: Anandakrishnan, Ramu, Varghese, Robin T., Kinney, Nicholas A., Garner, Harold R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424461/
https://www.ncbi.nlm.nih.gov/pubmed/30845172
http://dx.doi.org/10.1371/journal.pcbi.1006881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424461/
https://www.ncbi.nlm.nih.gov/pubmed/30845172
http://dx.doi.org/10.1371/journal.pcbi.1006881

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