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Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations
Individual instances of cancer are primarily a result of a combination of a small number of genetic mutations (hits). Knowing the number of such mutations is a prerequisite for identifying specific combinations of carcinogenic mutations and understanding the etiology of cancer. We present a mathemat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424461/ https://www.ncbi.nlm.nih.gov/pubmed/30845172 http://dx.doi.org/10.1371/journal.pcbi.1006881 |