Cargando…
Multiple functional neurosteroid binding sites on GABA(A) receptors
Neurosteroids are endogenous modulators of neuronal excitability and nervous system development and are being developed as anesthetic agents and treatments for psychiatric diseases. While gamma amino-butyric acid Type A (GABA(A)) receptors are the primary molecular targets of neurosteroid action, th...
Autores principales: | Chen, Zi-Wei, Bracamontes, John R., Budelier, Melissa M., Germann, Allison L., Shin, Daniel J., Kathiresan, Krishnan, Qian, Ming-Xing, Manion, Brad, Cheng, Wayland W. L., Reichert, David E., Akk, Gustav, Covey, Douglas F., Evers, Alex S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424464/ https://www.ncbi.nlm.nih.gov/pubmed/30845142 http://dx.doi.org/10.1371/journal.pbio.3000157 |
Ejemplares similares
-
Site-specific effects of neurosteroids on GABA(A) receptor activation and desensitization
por: Sugasawa, Yusuke, et al.
Publicado: (2020) -
The Mechanism of Enantioselective Neurosteroid Actions on GABA(A) Receptors
por: Tateiwa, Hiroki, et al.
Publicado: (2023) -
Neurosteroid Modulation of GABA(A) Receptor Function by Independent Action at Multiple Specific Binding Sites
por: Wang, Lei, et al.
Publicado: (2022) -
Perspective on the Relationship between GABA(A) Receptor Activity and the Apparent Potency of an Inhibitor
por: Germann, Allison L., et al.
Publicado: (2022) -
Kinetic and Structural Determinants for GABA-A Receptor Potentiation by Neuroactive Steroids
por: Akk, Gustav, et al.
Publicado: (2010)