Structural mechanisms of phospholipid activation of the human TPC2 channel

Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2))-activated, Na(+) selective channel, in the ligand-bound and apo states. The apo structure capt...

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Detalles Bibliográficos
Autores principales: She, Ji, Zeng, Weizhong, Guo, Jiangtao, Chen, Qingfeng, Bai, Xiao-chen, Jiang, Youxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424560/
https://www.ncbi.nlm.nih.gov/pubmed/30860481
http://dx.doi.org/10.7554/eLife.45222

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424560/
https://www.ncbi.nlm.nih.gov/pubmed/30860481
http://dx.doi.org/10.7554/eLife.45222

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