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Structural mechanisms of phospholipid activation of the human TPC2 channel

Mammalian two-pore channels (TPCs) regulate the physiological functions of the endolysosome. Here we present cryo-EM structures of human TPC2 (HsTPC2), a phosphatidylinositol 3,5-bisphosphate (PI(3,5)P(2))-activated, Na(+) selective channel, in the ligand-bound and apo states. The apo structure capt...

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Detalles Bibliográficos
Autores principales:	She, Ji, Zeng, Weizhong, Guo, Jiangtao, Chen, Qingfeng, Bai, Xiao-chen, Jiang, Youxing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2019
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424560/ https://www.ncbi.nlm.nih.gov/pubmed/30860481 http://dx.doi.org/10.7554/eLife.45222

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