LRRK2 deficiency induced mitochondrial Ca(2+) efflux inhibition can be rescued by Na(+)/Ca(2+)/Li(+) exchanger upregulation

Variants of leucine-rich repeat kinase 2 (lrrk2) are associated with an increased risk in developing Parkinson’s disease (PD). Mitochondrial dysfunction and specifically mitochondrial Ca(2+) handling has been linked to the pathogenesis of PD. Here we describe for the second time a mitochondrial Ca(2...

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Detalles Bibliográficos
Autores principales: Ludtmann, Marthe H. R., Kostic, Marko, Horne, Amy, Gandhi, Sonia, Sekler, Israel, Abramov, Andrey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424963/
https://www.ncbi.nlm.nih.gov/pubmed/30890692
http://dx.doi.org/10.1038/s41419-019-1469-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424963/
https://www.ncbi.nlm.nih.gov/pubmed/30890692
http://dx.doi.org/10.1038/s41419-019-1469-5

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