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Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation
Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution structural data of arrestins bound to phosphorylated receptor C-termini, the functional role of each phosphorylation si...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424980/ https://www.ncbi.nlm.nih.gov/pubmed/30890705 http://dx.doi.org/10.1038/s41467-019-09204-y |