Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

Cellular functions of arrestins are determined in part by the pattern of phosphorylation on the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution structural data of arrestins bound to phosphorylated receptor C-termini, the functional role of each phosphorylation si...

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Detalles Bibliográficos
Autores principales: Mayer, Daniel, Damberger, Fred F., Samarasimhareddy, Mamidi, Feldmueller, Miki, Vuckovic, Ziva, Flock, Tilman, Bauer, Brian, Mutt, Eshita, Zosel, Franziska, Allain, Frédéric H. T., Standfuss, Jörg, Schertler, Gebhard F. X., Deupi, Xavier, Sommer, Martha E., Hurevich, Mattan, Friedler, Assaf, Veprintsev, Dmitry B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424980/
https://www.ncbi.nlm.nih.gov/pubmed/30890705
http://dx.doi.org/10.1038/s41467-019-09204-y

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