TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis

Transcription and DNA damage repair act in a coordinated manner. Recent studies have shown that double-strand DNA breaks (DSBs) are repaired in a transcription-coupled manner. Active transcription results in a faster recruitment of DSB repair factors and expedites DNA repair. On the other hand, tran...

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Detalles Bibliográficos
Autores principales: Suzuki, Hidefumi, Okamoto-Katsuyama, Mayumi, Suwa, Tetsufumi, Maeda, Ryo, Tamura, Taka-aki, Yamaguchi, Yuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425004/
https://www.ncbi.nlm.nih.gov/pubmed/30890736
http://dx.doi.org/10.1038/s41598-019-41057-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425004/
https://www.ncbi.nlm.nih.gov/pubmed/30890736
http://dx.doi.org/10.1038/s41598-019-41057-9

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