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TLP-mediated global transcriptional repression after double-strand DNA breaks slows down DNA repair and induces apoptosis
Transcription and DNA damage repair act in a coordinated manner. Recent studies have shown that double-strand DNA breaks (DSBs) are repaired in a transcription-coupled manner. Active transcription results in a faster recruitment of DSB repair factors and expedites DNA repair. On the other hand, tran...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425004/ https://www.ncbi.nlm.nih.gov/pubmed/30890736 http://dx.doi.org/10.1038/s41598-019-41057-9 |