Glutathione-related substances maintain cardiomyocyte contractile function in hypoxic conditions

Severe hypoxia leads to decline in cardiac contractility and induces arrhythmic events in part due to oxidative damage to cardiomyocyte proteins including ion transporters. This results in compromised handling of Ca(2+) ions that trigger heart contractile machinery. Here, we demonstrate that thiol-c...

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Detalles Bibliográficos
Autores principales: Poluektov, Yuri M., Petrushanko, Irina Yu., Undrovinas, Nidas A., Lakunina, Valentina A., Khapchaev, Asker Y., Kapelko, Valery I., Abramov, Alexander A., Lakomkin, Vladimir L., Novikov, Mikhail S., Shirinsky, Vladimir P., Mitkevich, Vladimir A., Makarov, Alexander A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425009/
https://www.ncbi.nlm.nih.gov/pubmed/30890744
http://dx.doi.org/10.1038/s41598-019-41266-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425009/
https://www.ncbi.nlm.nih.gov/pubmed/30890744
http://dx.doi.org/10.1038/s41598-019-41266-2

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