The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms

Mutations in the Integral membrane protein 2B (ITM2b/BRI2) gene, which codes for a protein called BRI2, cause familial British and Danish dementia (FBD and FDD). Loss of BRI2 function and/or accumulation of amyloidogenic mutant BRI2-derived peptides have been proposed to mediate FDD and FBD pathogen...

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Detalles Bibliográficos
Autores principales: Yao, Wen, Yin, Tao, Tambini, Marc D., D’Adamio, Luciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425013/
https://www.ncbi.nlm.nih.gov/pubmed/30890756
http://dx.doi.org/10.1038/s41598-019-41340-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425013/
https://www.ncbi.nlm.nih.gov/pubmed/30890756
http://dx.doi.org/10.1038/s41598-019-41340-9

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