The APOE(∗)3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

BACKGROUND: There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase(+/−) (GK(+/−)) mice are a translatable disease model for gluco...

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Detalles Bibliográficos
Autores principales: Pouwer, Marianne G., Heinonen, Suvi E., Behrendt, Margareta, Andréasson, Anne-Christine, van Koppen, Arianne, Menke, Aswin L., Pieterman, Elsbet J., van den Hoek, Anita M., Jukema, J. Wouter, Leighton, Brendan, Jönsson-Rylander, Ann-Cathrine, Princen, Hans M. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425338/
https://www.ncbi.nlm.nih.gov/pubmed/30949516
http://dx.doi.org/10.1155/2019/9727952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425338/
https://www.ncbi.nlm.nih.gov/pubmed/30949516
http://dx.doi.org/10.1155/2019/9727952

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