Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique a...

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Detalles Bibliográficos
Autores principales: Krüger, Franziska, Kumar, Vipin, Monge, Pere, Conzelmann, Carina, Smith, Nikaïa, Gothelf, Kurt V., Tolstrup, Martin, Münch, Jan, Zelikin, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425433/
https://www.ncbi.nlm.nih.gov/pubmed/30937274
http://dx.doi.org/10.1002/advs.201802095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425433/
https://www.ncbi.nlm.nih.gov/pubmed/30937274
http://dx.doi.org/10.1002/advs.201802095

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