Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique a...

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Autores principales: Krüger, Franziska, Kumar, Vipin, Monge, Pere, Conzelmann, Carina, Smith, Nikaïa, Gothelf, Kurt V., Tolstrup, Martin, Münch, Jan, Zelikin, Alexander N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425433/
https://www.ncbi.nlm.nih.gov/pubmed/30937274
http://dx.doi.org/10.1002/advs.201802095
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author Krüger, Franziska
Kumar, Vipin
Monge, Pere
Conzelmann, Carina
Smith, Nikaïa
Gothelf, Kurt V.
Tolstrup, Martin
Münch, Jan
Zelikin, Alexander N.
author_facet Krüger, Franziska
Kumar, Vipin
Monge, Pere
Conzelmann, Carina
Smith, Nikaïa
Gothelf, Kurt V.
Tolstrup, Martin
Münch, Jan
Zelikin, Alexander N.
author_sort Krüger, Franziska
collection PubMed
description Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.
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spelling pubmed-64254332019-04-01 Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues Krüger, Franziska Kumar, Vipin Monge, Pere Conzelmann, Carina Smith, Nikaïa Gothelf, Kurt V. Tolstrup, Martin Münch, Jan Zelikin, Alexander N. Adv Sci (Weinh) Communications Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies. John Wiley and Sons Inc. 2019-01-28 /pmc/articles/PMC6425433/ /pubmed/30937274 http://dx.doi.org/10.1002/advs.201802095 Text en © 2019 The Authors. Published by WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Krüger, Franziska
Kumar, Vipin
Monge, Pere
Conzelmann, Carina
Smith, Nikaïa
Gothelf, Kurt V.
Tolstrup, Martin
Münch, Jan
Zelikin, Alexander N.
Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
title Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
title_full Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
title_fullStr Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
title_full_unstemmed Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
title_short Nucleic Acids as a Nature‐Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues
title_sort nucleic acids as a nature‐inspired scaffold for macromolecular prodrugs of nucleoside analogues
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425433/
https://www.ncbi.nlm.nih.gov/pubmed/30937274
http://dx.doi.org/10.1002/advs.201802095
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