Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common

BACKGROUND: Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not improved in 50 years. Osteosarcoma still has a 5-year survival rate of 66%. We propose the natural canine osteosarcoma model can change that: it is extremely similar...

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Detalles Bibliográficos
Autores principales: Zapata, Isain, Moraes, Luis E., Fiala, Elise M., Zaldivar-Lopez, Sara, Couto, C. Guillermo, Rowell, Jennie L., Alvarez, Carlos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425649/
https://www.ncbi.nlm.nih.gov/pubmed/30890123
http://dx.doi.org/10.1186/s12864-019-5531-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425649/
https://www.ncbi.nlm.nih.gov/pubmed/30890123
http://dx.doi.org/10.1186/s12864-019-5531-6

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