Recombinant RGD-disintegrin DisBa-01 blocks integrin α(v)β(3) and impairs VEGF signaling in endothelial cells

BACKGROUND: Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between α(v)β(3) integrin and VEGF type 2 receptor (VEGFR2) in VEGF-induced angiogenesis. DisBa-01,...

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Detalles Bibliográficos
Autores principales: Danilucci, Taís M., Santos, Patty K., Pachane, Bianca C., Pisani, Graziéle F. D., Lino, Rafael L. B., Casali, Bruna C., Altei, Wanessa F., Selistre-de-Araujo, Heloisa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425665/
https://www.ncbi.nlm.nih.gov/pubmed/30894182
http://dx.doi.org/10.1186/s12964-019-0339-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425665/
https://www.ncbi.nlm.nih.gov/pubmed/30894182
http://dx.doi.org/10.1186/s12964-019-0339-1

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