Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy

Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process results in aberrant gene expression in various diseases, including cancer. The bromodomain, present in several proteins, recognizes promotor lysine acetylation and recruits other transcription factors....

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Detalles Bibliográficos
Autores principales: Alqahtani, Ali, Choucair, Khalil, Ashraf, Mushtaq, Hammouda, Danae M, Alloghbi, Abduraham, Khan, Talal, Senzer, Neil, Nemunaitis, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426170/
https://www.ncbi.nlm.nih.gov/pubmed/30906568
http://dx.doi.org/10.4155/fsoa-2018-0115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426170/
https://www.ncbi.nlm.nih.gov/pubmed/30906568
http://dx.doi.org/10.4155/fsoa-2018-0115

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