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Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy
Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process results in aberrant gene expression in various diseases, including cancer. The bromodomain, present in several proteins, recognizes promotor lysine acetylation and recruits other transcription factors....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Future Science Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426170/ https://www.ncbi.nlm.nih.gov/pubmed/30906568 http://dx.doi.org/10.4155/fsoa-2018-0115 |