Expanded CUG repeats in DMPK transcripts adopt diverse hairpin conformations without influencing the structure of the flanking sequences

Myotonic dystrophy type 1 (DM1) is a complex neuromuscular disorder caused by expansion of a CTG repeat in the 3′-untranslated region (UTR) of the DMPK gene. Mutant DMPK transcripts form aberrant structures and anomalously associate with RNA-binding proteins (RBPs). As a first step toward better und...

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Detalles Bibliográficos
Autores principales: van Cruchten, Remco T.P., Wieringa, Bé, Wansink, Derick G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426290/
https://www.ncbi.nlm.nih.gov/pubmed/30700578
http://dx.doi.org/10.1261/rna.068940.118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426290/
https://www.ncbi.nlm.nih.gov/pubmed/30700578
http://dx.doi.org/10.1261/rna.068940.118

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