Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth
Densely arranged N-linked glycans shield the HIV-1 envelope (Env) trimer from antibody recognition. Strain-specific breaches in this shield (glycan holes) can be targets of vaccine-induced neutralizing antibodies that lack breadth. To understand the interplay between glycan holes and neutralization...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426304/ https://www.ncbi.nlm.nih.gov/pubmed/30355496 http://dx.doi.org/10.1016/j.celrep.2018.09.087 |