Cargando…
Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence
The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show that Mtb lacking the stringent response enzyme Rel(Mtb) was unable to slow its replication rate during nutrient starvation. Metabolomics analysis revealed...
Autores principales: | , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426458/ https://www.ncbi.nlm.nih.gov/pubmed/30906866 http://dx.doi.org/10.1126/sciadv.aav2104 |