Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence

The stringent response enables Mycobacterium tuberculosis (Mtb) to shut down its replication and metabolism under various stresses. Here we show that Mtb lacking the stringent response enzyme Rel(Mtb) was unable to slow its replication rate during nutrient starvation. Metabolomics analysis revealed...

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Detalles Bibliográficos
Autores principales: Dutta, Noton K., Klinkenberg, Lee G., Vazquez, Maria-Jesus, Segura-Carro, Delfina, Colmenarejo, Gonzalo, Ramon, Fernando, Rodriguez-Miquel, Beatriz, Mata-Cantero, Lydia, Porras-De Francisco, Esther, Chuang, Yu-Min, Rubin, Harvey, Lee, Jae Jin, Eoh, Hyungjin, Bader, Joel S., Perez-Herran, Esther, Mendoza-Losana, Alfonso, Karakousis, Petros C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426458/
https://www.ncbi.nlm.nih.gov/pubmed/30906866
http://dx.doi.org/10.1126/sciadv.aav2104

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