pH-dependent gating mechanism of the Helicobacter pylori urea channel revealed by cryo-EM

The urea channel of Helicobacter pylori (HpUreI) is an ideal drug target for preventing gastric cancer but incomplete understanding of its gating mechanism has hampered development of inhibitors for the eradication of H. pylori. Here, we present the cryo-EM structures of HpUreI in closed and open co...

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Detalles Bibliográficos
Autores principales: Cui, Yanxiang, Zhou, Kang, Strugatsky, David, Wen, Yi, Sachs, George, Zhou, Z. Hong, Munson, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426461/
https://www.ncbi.nlm.nih.gov/pubmed/30906870
http://dx.doi.org/10.1126/sciadv.aav8423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426461/
https://www.ncbi.nlm.nih.gov/pubmed/30906870
http://dx.doi.org/10.1126/sciadv.aav8423

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