Matching Mitochondrial DNA Haplotypes for Circumventing Tissue-Specific Segregation Bias

Mitochondrial DNA (mtDNA) segregation associated with donor-recipient mtDNA mismatch in mitochondria replacement therapy leads to unknown risks. Here, to explore whether matching mtDNA haplotypes contributes to ameliorating segregation, we reproduced various degrees of heteroplasmic mice with three...

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Detalles Bibliográficos
Autores principales: Pan, Jianxin, Wang, Li, Lu, Charles, Zhu, Yanming, Min, Zhunyuan, Dong, Xi, Sha, Hongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426714/
https://www.ncbi.nlm.nih.gov/pubmed/30897510
http://dx.doi.org/10.1016/j.isci.2019.03.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426714/
https://www.ncbi.nlm.nih.gov/pubmed/30897510
http://dx.doi.org/10.1016/j.isci.2019.03.002

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