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Matching Mitochondrial DNA Haplotypes for Circumventing Tissue-Specific Segregation Bias
Mitochondrial DNA (mtDNA) segregation associated with donor-recipient mtDNA mismatch in mitochondria replacement therapy leads to unknown risks. Here, to explore whether matching mtDNA haplotypes contributes to ameliorating segregation, we reproduced various degrees of heteroplasmic mice with three...
Autores principales: | Pan, Jianxin, Wang, Li, Lu, Charles, Zhu, Yanming, Min, Zhunyuan, Dong, Xi, Sha, Hongying |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426714/ https://www.ncbi.nlm.nih.gov/pubmed/30897510 http://dx.doi.org/10.1016/j.isci.2019.03.002 |
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