Implications of Individual QT/RR Profiles—Part 2: Zero QTc/RR Correlations Do Not Prove QTc Correction Accuracy in Studies of QTc Changes

INTRODUCTION: In studies of drug-induced corrected QT (QTc) changes, fixed universal heart rate (HR) corrections (e.g., the Fridericia correction) are potentially misleading when assessing the effects of drugs that change HR. When data-specific corrections are designed, tests of their validity are n...

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Detalles Bibliográficos
Autores principales: Malik, Marek, Garnett, Christine, Hnatkova, Katerina, Vicente, Jose, Johannesen, Lars, Stockbridge, Norman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426831/
https://www.ncbi.nlm.nih.gov/pubmed/30255348
http://dx.doi.org/10.1007/s40264-018-0735-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426831/
https://www.ncbi.nlm.nih.gov/pubmed/30255348
http://dx.doi.org/10.1007/s40264-018-0735-2

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