Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization

Cancer cells re-program their metabolic machinery to meet the requirements of malignant transformation and progression. Glutaminase 1 (GLS1) was traditionally known as a mitochondrial enzyme that hydrolyzes glutamine into glutamate and fuels rapid proliferation of cancer cells. However, emerging evi...

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Detalles Bibliográficos
Autores principales: Xiang, Lisha, Mou, Jun, Shao, Bin, Wei, Yuquan, Liang, Houjie, Takano, Naoharu, Semenza, Gregg L., Xie, Ganfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426853/
https://www.ncbi.nlm.nih.gov/pubmed/30674873
http://dx.doi.org/10.1038/s41419-018-1291-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426853/
https://www.ncbi.nlm.nih.gov/pubmed/30674873
http://dx.doi.org/10.1038/s41419-018-1291-5

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