Extensive epigenetic and transcriptomic variability between genetically identical human B-lymphoblastoid cells with implications in pharmacogenomics research

Genotyped human B-lymphoblastoid cell lines (LCLs) are widely used models in mapping quantitative trait loci for chromatin features, gene expression, and drug response. The extent of genotype-independent functional genomic variability of the LCL model, although largely overlooked, may inform associa...

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Detalles Bibliográficos
Autores principales: Ozgyin, Lilla, Horvath, Attila, Hevessy, Zsuzsanna, Balint, Balint L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426863/
https://www.ncbi.nlm.nih.gov/pubmed/30894562
http://dx.doi.org/10.1038/s41598-019-40897-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426863/
https://www.ncbi.nlm.nih.gov/pubmed/30894562
http://dx.doi.org/10.1038/s41598-019-40897-9

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