Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes

Gfi1b is a transcriptional repressor expressed in hematopoietic stem cells (HSCs) and megakaryocytes (MKs). Gfi1b deficiency leads to expansion of both cell types and abrogates the ability of MKs to respond to integrin. Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52,...

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Detalles Bibliográficos
Autores principales: Shooshtarizadeh, Peiman, Helness, Anne, Vadnais, Charles, Brouwer, Nelleke, Beauchemin, Hugues, Chen, Riyan, Bagci, Halil, Staal, Frank J. T., Coté, Jean-François, Möröy, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426870/
https://www.ncbi.nlm.nih.gov/pubmed/30894540
http://dx.doi.org/10.1038/s41467-019-09273-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426870/
https://www.ncbi.nlm.nih.gov/pubmed/30894540
http://dx.doi.org/10.1038/s41467-019-09273-z

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