Optogenetic stimulation of G(s)-signaling in the heart with high spatio-temporal precision

The standard technique for investigating adrenergic effects on heart function is perfusion with pharmaceutical agonists, which does not provide high temporal or spatial precision. Herein we demonstrate that the light sensitive G(s)-protein coupled receptor JellyOp enables optogenetic stimulation of...

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Detalles Bibliográficos
Autores principales: Makowka, Philipp, Bruegmann, Tobias, Dusend, Vanessa, Malan, Daniela, Beiert, Thomas, Hesse, Michael, Fleischmann, Bernd K., Sasse, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426906/
https://www.ncbi.nlm.nih.gov/pubmed/30894542
http://dx.doi.org/10.1038/s41467-019-09322-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426906/
https://www.ncbi.nlm.nih.gov/pubmed/30894542
http://dx.doi.org/10.1038/s41467-019-09322-7

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