The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation

Hsp90 is a dimeric molecular chaperone that is essential for the folding and activation of hundreds of client proteins. Co-chaperone proteins regulate the ATP-driven Hsp90 client activation cycle. Aha-type co-chaperones are the most potent stimulators of the Hsp90 ATPase activity but the relationshi...

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Detalles Bibliográficos
Autores principales: Mercier, Rebecca, Wolmarans, Annemarie, Schubert, Jonathan, Neuweiler, Hannes, Johnson, Jill L., LaPointe, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426937/
https://www.ncbi.nlm.nih.gov/pubmed/30894538
http://dx.doi.org/10.1038/s41467-019-09299-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426937/
https://www.ncbi.nlm.nih.gov/pubmed/30894538
http://dx.doi.org/10.1038/s41467-019-09299-3

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