Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor

Porphyromonas gingivalis is a member of the dysbiotic oral microbiome and a “keystone pathogen” that causes severe periodontal disease, which is among the most prevalent infectious diseases. Part of the virulence factors secreted by P. gingivalis are the essential cysteine peptidases gingipain K (Kg...

Descripción completa

Detalles Bibliográficos
Autores principales: Guevara, Tibisay, Rodríguez-Banqueri, Arturo, Lasica, Anna M., Ksiazek, Miroslaw, Potempa, Barbara A., Potempa, Jan, Gomis-Rüth, F. Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426963/
https://www.ncbi.nlm.nih.gov/pubmed/30894633
http://dx.doi.org/10.1038/s41598-019-41354-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426963/
https://www.ncbi.nlm.nih.gov/pubmed/30894633
http://dx.doi.org/10.1038/s41598-019-41354-3

Ejemplares similares