Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis

The PBX1 homeodomain transcription factor is converted by t(1;19) chromosomal translocations in acute leukemia into the chimeric E2A-PBX1 oncoprotein. Fusion with E2A confers potent transcriptional activation and constitutive nuclear localization, bypassing the need for dimerization with protein par...

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Detalles Bibliográficos
Autores principales: Lin, Chiou-Hong, Wang, Zhong, Duque-Afonso, Jesús, Wong, Stephen Hon-Kit, Demeter, Janos, Loktev, Alexander V., Somervaille, Tim C. P., Jackson, Peter K., Cleary, Michael L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426973/
https://www.ncbi.nlm.nih.gov/pubmed/30894657
http://dx.doi.org/10.1038/s41598-019-41393-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426973/
https://www.ncbi.nlm.nih.gov/pubmed/30894657
http://dx.doi.org/10.1038/s41598-019-41393-w

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